An intrabursal injection of β-endorphin stimulated nitric oxide synthase (NOS) activity. Immature rats were treated with equine chorionic gonadotrophin-hCG to induce ovulation. In conclusion, these results indicate that β-endorphin stimulates the activity of ovarian NOS indirectly by inhibiting prostaglandin production.ĪB - The aim of this study was to investigate the relationship between β-endorphin and nitric oxide (NO) during the ovulatory process in rats. Treatment with prostaglandin synthesis inhibitors in vivo augmented the ovarian β-endorphin content. Ovarian β-endorphin content was diminished at 10 h after hCG injection. Local administration of β-endorphin inhibited the expression of eNOS protein, whereas expression of iNOS protein was not detectable. The presence of both endothelial NOS (eNOS) and inducible NOS (iNOS) in the ovary at 10 h after hCG treatment was studied by western blot analysis. Moreover, intrabursal injection of meloxicam, an inhibitor of cyclooxygenase 2, increased NOS activity, but this effect was not altered by co-injection with β-endorphin. Treatment with prostaglandin E2 (PGE2) completely reversed the β-endorphin-induced stimulation of NOS activity. The stimulatory action of β-endorphin on NOS activity was studied to determine whether it was exerted via prostaglandins. This effect was completely reversed when naltrexone was co-injected with β-endorphin. N2 - The aim of this study was to investigate the relationship between β-endorphin and nitric oxide (NO) during the ovulatory process in rats. T1 - Interaction among beta-endorphin, nitric oxide and prostaglandins during ovulation in rats In conclusion, these results indicate that β-endorphin stimulates the activity of ovarian NOS indirectly by inhibiting prostaglandin production.", In conclusion, these results indicate that β-endorphin stimulates the activity of ovarian NOS indirectly by inhibiting prostaglandin production.Ībstract = "The aim of this study was to investigate the relationship between β-endorphin and nitric oxide (NO) during the ovulatory process in rats. Treatment with prostaglandin E 2 (PGE 2) completely reversed the β-endorphin-induced stimulation of NOS activity. The aim of this study was to investigate the relationship between β-endorphin and nitric oxide (NO) during the ovulatory process in rats.
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